abstract：:Lin28 is an evolutionary conserved RNA-binding protein that plays important roles during embryonic development and tumorigenesis. It regulates gene expression through two different post-transcriptional mechanisms. The first one is based on the regulation of miRNA biogenesis, in particular that of the let-7 family, who...

journal_title：Scientific reports

authors： Parisi S,Castaldo D,Piscitelli S,D'Ambrosio C,Divisato G,Passaro F,Avolio R,Castellucci A,Gianfico P,Masullo M,Scaloni A,Russo T

更新日期：2021-01-27 00:00:00

abstract：:Tissue microarray (TMA) core images are a treasure trove for artificial intelligence applications. However, a common problem of TMAs is multiple sectioning, which can change the content of the intended tissue core and requires re-labelling. Here, we investigate different ensemble methods for colorectal tissue classifi...

journal_title：Scientific reports

authors： Nguyen HG,Blank A,Dawson HE,Lugli A,Zlobec I

更新日期：2021-01-27 00:00:00

abstract：:The association between alcohol consumption and kidney function is intriguing, but study results are mixed and controversial. We examined the association of alcohol consumption with the overall change in kidney function over 12 years. We analyzed data from a population-based cohort that was part of the Korean Genome a...

journal_title：Scientific reports

authors： Lee YJ,Cho S,Kim SR

更新日期：2021-01-27 00:00:00

abstract：:Tropical Pacific stalagmites are commonly affected by dating uncertainties because of their low U concentration and/or elevated initial 230Th content. This poses problems in establishing reliable trends and periodicities for droughts and pluvial episodes in a region vulnerable to climate change. Here we constrain the ...

journal_title：Scientific reports

authors： Faraji M,Borsato A,Frisia S,Hellstrom JC,Lorrey A,Hartland A,Greig A,Mattey DP

更新日期：2021-01-26 00:00:00

abstract：:Our mind's eye and the role of internal attention in mental life and suffering has intrigued scholars for centuries. Yet, experimental study of internal attention has been elusive due to our limited capacity to control the timing and content of internal stimuli. We thus developed the Simulated Thoughts Paradigm (STP) ...

journal_title：Scientific reports

authors： Amir I,Ruimi L,Bernstein A

更新日期：2021-01-26 00:00:00

abstract：:Ovarian tissue cryopreservation is considered as a useful option to preserve fertility for cancer patients. This study purposed to evaluate the change of telomere length and senescence markers during human ovarian tissue cryopreservation. Ovarian tissues were obtained from women who underwent benign ovarian surgery in...

journal_title：Scientific reports

authors： Kim B,Ryu KJ,Lee S,Kim T

更新日期：2021-01-26 00:00:00

abstract：:A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia. Although near vision impairment is a social issue affecting the length of healthy life expectancy and productivity of elderly people, an effective treatment to improve ne...

journal_title：Scientific reports

authors： Nagashima H,Sasaki N,Amano S,Nakamura S,Hayano M,Tsubota K

更新日期：2021-01-26 00:00:00

abstract：:Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumor carrying poor prognosis and needing new treatment options. The aim of this study was to identify actionable gene mutations that can guide new personalized target-specific therapies in ITAC patients. A series of 48 tumor and 27 corresponding germline DNA s...

journal_title：Scientific reports

authors： Sánchez-Fernández P,Riobello C,Costales M,Vivanco B,Cabal VN,García-Marín R,Suárez-Fernández L,López F,Cabanillas R,Hermsen MA,Llorente JL

更新日期：2021-01-26 00:00:00

abstract：:Measurement of intracranial aneurysm wall motion may refine the current rupture risk estimation. A golden standard for measuring aneurysm pulsation is lacking. The aim is to evaluate magnitudes of aneurysm pulsation as published in current literature. Embase and PubMed were searched for publications containing quantit...

journal_title：Scientific reports

authors： Stam LB,Aquarius R,de Jong GA,Slump CH,Meijer FJA,Boogaarts HD

更新日期：2021-01-26 00:00:00

abstract：:Long-term skills training is known to induce neuroplastic alterations, but it is still debated whether these changes are always modality-specific or can be supramodal components. To address this issue, we compared finger-targeted somatosensory-evoked and auditory-evoked potentials under both Go (response) and Nogo (re...

journal_title：Scientific reports

authors： Yamashiro K,Yamazaki Y,Siiya K,Ikarashi K,Baba Y,Otsuru N,Onishi H,Sato D

更新日期：2021-01-26 00:00:00

abstract：:Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood test...

journal_title：Scientific reports

authors： Yokota T,Kinugawa S,Hirabayashi K,Yamato M,Takada S,Suga T,Nakano I,Fukushima A,Matsushima S,Okita K,Tsutsui H

更新日期：2021-01-26 00:00:00

abstract：:Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel lymph node biopsy (SLNB) is a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB status. 1556 patients with a ...

journal_title：Scientific reports

authors： Rossing M,Pedersen CB,Tvedskov T,Vejborg I,Talman ML,Olsen LR,Kroman N,Nielsen FC,Jensen MB,Ejlertsen B

更新日期：2021-01-26 00:00:00

abstract：:The activation and growth of tumour-initiating cells with stem-like properties in distant organs characterize colorectal cancer (CRC) growth and metastasis. Thus, inhibition of colon cancer stem cell (CCSC) growth holds promise for CRC growth and metastasis prevention. We and others have shown that farnesyl dimethyl c...

journal_title：Scientific reports

authors： Husain K,Coppola D,Yang CS,Malafa MP

更新日期：2021-01-26 00:00:00

abstract：:The myxozoan parasite, Tetracapsuloides bryosalmonae has a two-host life cycle alternating between freshwater bryozoans and salmonid fish. Infected fish can develop Proliferative Kidney Disease, characterised by a gross lymphoid-driven kidney pathology in wild and farmed salmonids. To facilitate an in-depth understand...

journal_title：Scientific reports

authors： Faber M,Shaw S,Yoon S,de Paiva Alves E,Wang B,Qi Z,Okamura B,Hartikainen H,Secombes CJ,Holland JW

更新日期：2021-01-25 00:00:00

abstract：:The reliable identification of diffuse large B-cell lymphoma (DLBCL)-specific targets owns huge implications for its diagnosis and treatment. Long non-coding RNAs (lncRNAs) are implicated in DLBCL pathogenesis; however, circulating DLBCL-related lncRNAs are barely investigated. We investigated plasma lncRNAs; HOTAIR, ...

journal_title：Scientific reports

authors： Senousy MA,El-Abd AM,Abdel-Malek RR,Rizk SM

更新日期：2021-01-22 00:00:00

abstract：:The characteristics of aortic valvular outflow jet affect aortopathy in the bicuspid aortic valve (BAV). This study aimed to elucidate the effects of BAV morphology on the aortic valvular outflow jets. Morphotype-specific valve-devising apparatuses were developed to create aortic valve models. A magnetic resonance ima...

journal_title：Scientific reports

authors： Hattori K,Nakama N,Takada J,Nishimura G,Moriwaki R,Kawasaki E,Nagao M,Goto Y,Niinami H,Iwasaki K

更新日期：2021-01-22 00:00:00

abstract：:In the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2 modified by isatoic anhydride. The structure of the catalyst has been determined by ...

journal_title：Scientific reports

authors： Rajabi-Moghaddam H,Naimi-Jamal MR,Tajbakhsh M

更新日期：2021-01-22 00:00:00

abstract：:Candida albicans (C. albicans) is the most common cause of candidiasis in humans and animals. This study was established to a new experimental infection model for systemic candidiasis using partridge and embryonated partridge egg. First, we tested the induction of systemic candidiasis in partridge and embryonated part...

journal_title：Scientific reports

authors： Tavakkoli H,Khosravi A,Sharifi I,Salari Z,Salarkia E,Kheirandish R,Dehghantalebi K,Jajarmi M,Mosallanejad SS,Dabiri S,Keyhani A

更新日期：2021-01-22 00:00:00

abstract：:Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson's disease, whereas our previous analyses of public cancer patient data revealed that decreased LRRK2 expression is associated with lung adenocarcinoma (LUAD). The clinical and functional relevance ...

journal_title：Scientific reports

authors： Lebovitz C,Wretham N,Osooly M,Milne K,Dash T,Thornton S,Tessier-Cloutier B,Sathiyaseelan P,Bortnik S,Go NE,Halvorsen E,Cederberg RA,Chow N,Dos Santos N,Bennewith KL,Nelson BH,Bally MB,Lam WL,Gorski SM

更新日期：2021-01-22 00:00:00

abstract：:We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel, whereas dendrites and soma remain predominantly in the somal co...

journal_title：Scientific reports

authors： Spijkers XM,Pasteuning-Vuhman S,Dorleijn JC,Vulto P,Wevers NR,Pasterkamp RJ

更新日期：2021-01-22 00:00:00

abstract：:An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields. ...

journal_title：Scientific reports

authors： Hua TB,Liu CX,Hu WM,Wang L,Yang QQ

更新日期：2021-01-22 00:00:00

abstract：:Parvalbumin-containing projection neurons of the medial-septum-diagonal band of Broca ([Formula: see text]) are essential for hippocampal rhythms and learning operations yet are poorly understood at cellular and synaptic levels. We combined electrophysiological, optogenetic, and modeling approaches to investigate [For...

journal_title：Scientific reports

authors： Yi F,Garrett T,Deisseroth K,Haario H,Stone E,Lawrence JJ

更新日期：2021-01-22 00:00:00

abstract：:Anaerobic ammonium oxidation (anammox) bacteria significantly improve the efficiency and reduce cost of nitrogen removal in wastewater treatment plants. However, their slow growth and vulnerable activity limit the application of anammox technology. In this paper, the enhancement of biotin on the nitrogen removal activ...

journal_title：Scientific reports

authors： Li Q,Chen J,Liu GH,Xu X,Zhang Q,Wang Y,Yuan J,Li Y,Qi L,Wang H

更新日期：2021-01-21 00:00:00

abstract：:We used swept-source (SS) optical coherence tomography (OCT) and OCT angiography (OCTA) to investigate the effects of moderate physical exercise on retinal and choroidal vessel densities (VDs) and thicknesses in children. One eye in each of 40 myopic children (mean age, 11.70 years) and 18 emmetropic children (mean ag...

journal_title：Scientific reports

authors： Li S,Pan Y,Xu J,Li X,Spiegel DP,Bao J,Chen H

更新日期：2021-01-21 00:00:00

abstract：:This paper studies the social acceptability and feasibility of a focused protection strategy against coronavirus disease 2019 (COVID-19). We propose a control scheme to develop herd immunity while satisfying the following two basic requirements for a viable policy option. The first requirement is social acceptability:...

journal_title：Scientific reports

authors： Akamatsu T,Nagae T,Osawa M,Satsukawa K,Sakai T,Mizutani D

更新日期：2021-01-21 00:00:00

abstract：:Intuition and insight can be deployed on the same continuum. Intuition is the unconscious ability to create links between information; insight is a process by which a sudden comprehension and resolution of a situation arises (i.e. euréka). In the present study, real and virtual environments were used to trigger intuit...

journal_title：Scientific reports

authors： Eskinazi M,Giannopulu I

更新日期：2021-01-21 00:00:00

abstract：:Acute traumatic intraparenchymal hematoma (tICH) expansion is a devastating neurological complication that is associated with poor outcome after cerebral contusion. This study aimed to develop and validate a novel noncontrast computed tomography (CT) (NCCT) multihematoma fuzzy sign to predict acute tICH expansion. In ...

journal_title：Scientific reports

authors： Sheng J,Yang J,Cai S,Zhuang D,Li T,Chen X,Wang G,Dai J,Ding F,Tian L,Zheng F,Tian F,Huang M,Li K,Chen W

更新日期：2021-01-21 00:00:00

abstract：:The Expanded Susceptibility to Smoking Index (ESSI) is based on the combination of susceptibility to smoking and curiosity about smoking. The ESSI can identify young people who are at risk of starting to smoke cigarettes and related products. The objective of this study was to analyse the ESSI results and to examine f...

journal_title：Scientific reports

authors： Santano-Mogena E,Franco-Antonio C,Chimento-Díaz S,Rico-Martín S,Cordovilla-Guardia S

更新日期：2021-01-21 00:00:00

abstract：:We examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square tests were used to determin...

journal_title：Scientific reports

authors： Wu Z,Yuan Y,Tian J,Long F,Luo W

更新日期：2021-01-21 00:00:00

abstract：:In this study, we aimed to elucidate the origin of domestic chickens and their evolutionary history over the course of their domestication. We conducted a large-scale genetic study using mitochondrial DNA D-loop sequences and 28 microsatellite DNA markers to investigate the diversity of 298 wild progenitor red junglef...

journal_title：Scientific reports

authors： Hata A,Nunome M,Suwanasopee T,Duengkae P,Chaiwatana S,Chamchumroon W,Suzuki T,Koonawootrittriron S,Matsuda Y,Srikulnath K

更新日期：2021-01-21 00:00:00

abstract：:Transverse-tubules (T-tubules) play pivotal roles in Ca2+-induced, Ca2+ release and excitation-contraction coupling in cardiomyocytes. The purpose of this study was to uncover mechanisms where sarco/endoplasmic reticulum Ca2+ ATPase (SERCA2a) improved cardiac function through T-tubule regulation during myocardial isch...

journal_title：Scientific reports

authors： Wang S,Zhou Y,Luo Y,Kan R,Chen J,Xuan H,Wang C,Chen J,Xu T,Li D

更新日期：2021-01-21 00:00:00

abstract：:The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in the open-field and fear condit...

journal_title：Scientific reports

authors： Hoang Trung H,Yoshihara T,Nakao A,Hayashida K,Hirata Y,Shirasuna K,Kuwamura M,Nakagawa Y,Kaneko T,Mori Y,Asano M,Kuramoto T

更新日期：2021-01-21 00:00:00

abstract：:Recurrence risk stratification of patients undergoing primary surgical resection for hepatocellular carcinoma (HCC) is an area of active investigation, and several staging systems have been proposed to optimize treatment strategies. However, as many as 70% of patients still experience tumor recurrence at 5 years post-...

journal_title：Scientific reports

authors： Yamashita R,Long J,Saleem A,Rubin DL,Shen J

更新日期：2021-01-21 00:00:00

abstract：:Although redox reactions are recognized to fractionate iron (Fe) isotopes, the dominant mechanisms controlling the Fe isotope fractionation and notably the role of organic matter (OM) are still debated. Here, we demonstrate how binding to organic ligands governs Fe isotope fractionation beyond that arising from redox ...

journal_title：Scientific reports

authors： Lotfi-Kalahroodi E,Pierson-Wickmann AC,Rouxel O,Marsac R,Bouhnik-Le Coz M,Hanna K,Davranche M

更新日期：2021-01-21 00:00:00

abstract：:Patients with stress-induced exhaustion disorder (SED) demonstrate cognitive dysfunction similar to patients with minor traumatic brain injury (TBI). We have previously detected elevated concentrations of astrocyte-derived extracellular vesicles (EVs) in patients with TBI. As such, we hypothesized that astrocyte-deriv...

journal_title：Scientific reports

authors： Wallensten J,Nager A,Åsberg M,Borg K,Beser A,Wilczek A,Mobarrez F

更新日期：2021-01-21 00:00:00

abstract：:Plant derived biogenic synthesis of nanoparticles (NP) has been the recent trend in material science as featured sustainable catalysts. A great deal of the current nanocatalytic research has been oriented on the bio-inspired green catalysts based on their wide applicability. In this context, CuO NPs are synthesized fo...

journal_title：Scientific reports

authors： Veisi H,Karmakar B,Tamoradi T,Hemmati S,Hekmati M,Hamelian M

更新日期：2021-01-21 00:00:00

abstract：:Diabetes mellitus (DM) exhibits a higher sensitivity to myocardial ischemia/reperfusion (I/R) injury and may compromise the effectiveness of cardioprotective interventions, including ischemic preconditioning. We previously found that liver ischemic preconditioning (RLIPC) could limit infarct size post I/R in non-diabe...

journal_title：Scientific reports

authors： Liu X,Chen H,Yan Z,Du L,Huang D,Gao WD,Hu Z

更新日期：2021-01-21 00:00:00

abstract：:A dusty thermal vacuum chamber (DTVC) containing a regolith simulant bed is essential for testing equipment and techniques related to lunar surface exploration. Space agencies have been reluctant to operate a DTVC because of the challenge of controlling soil disturbance of the lunar regolith simulant bed during pumpin...

journal_title：Scientific reports

authors： Go GH,Lee J,Chung T,Ryu BH,Jin H,Zhuang L,Shin HS,Kim JH,Yun TS

更新日期：2021-01-21 00:00:00

abstract：:The increased prevalence of childhood obesity is expected to translate in the near future into a concomitant soaring of multiple cardio-metabolic diseases. Obesity has a complex, multifactorial etiology, that includes multiple and multidomain potential risk factors: genetics, dietary and physical activity habits, soci...

journal_title：Scientific reports

authors： Marcos-Pasero H,Colmenarejo G,Aguilar-Aguilar E,Ramírez de Molina A,Reglero G,Loria-Kohen V

更新日期：2021-01-21 00:00:00

abstract：:This study evaluates the forensic utility of 23 autosomal short tandem repeat markers in 400 samples from the Kuwaiti population, of which four markers (D10S1248, D22S1045, D2S441 and SE33) are reported for the first time for Kuwait. All the markers were shown to exhibit no deviation from Hardy-Weinberg equilibrium, n...

journal_title：Scientific reports

authors： Haidar M,Abbas FA,Alsaleh H,Haddrill PR

更新日期：2021-01-21 00:00:00